ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Neuronal Nitric Oxide Expression In Benign Prostatic Hyperplasia
Emin ÖZBEK*, Bülent MIZRAK**, Ahmet SOYLU***
* Dept. of Urology Medical School of Gaziantep University, GAZİANTEP
** Dept. of Pathology Medical School of Inonu University,
*** Dept. of Urology Medical School of Inonu University, Malatya, TURKEY
Recently nitric oxide (NO) has been suggested to be a non-adrenergic non-cholinergic (NANC) neurotransmitter in the lower urinary tract. In this study we aimed to determine the location of the neuronal nitric oxide (nNOS) in the human prostate and compare the results with urinary retention and nonretention patients. nNOS immunohistochemistry were performed on histopatologically proven benign hyperplastic tissue. Patients were divided into two groups as a patients with urinary retention and non retention. nNOS staining was negative in all of patients with urinary retention, however, it was negative in 12 of 20 patients and weak positive in 8 in noncathetherized patients. Another finding was the negative staining in areas which bazal cell proliferation were seen, however strong staining were observed in the areas of containing atrophic glands. The pattern of glandular nNOS was relatively homogeneous in all specimens.
As a result, in patients with urinary retention, nNOS expression is reduced compared to that in noncathetherised patients. This study also shows that nitrinergic innervation is reduced in patients with urinary retention. This result may be the cause or result of urinary retention in BPH patients. Further studies are needed to confirm the role of nNOS in the pathophysiology of BPH.Keywords: nitric oxide, benign prostatic hyperplasia,
urinary retentionTurkiye Klinikleri J Med Sci 2000, 20:216-220
|
|
|
|
|
