ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Investigation Of The Effects Of 5-flurouracil Onantioxidant Enzyme Activity In Rabbits
Mehmet AKDOĞAN*, Süleyman KALELİ**, Fatih GÜLTEKİN*,Hüsamettin VATANSEV***, Harun KIZILAY*
* Dr., Süleyman Demirel Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD,** Dr., Süleyman Demirel Üniversitesi Sağlık Yüksekokulu, ISPARTA*** Dr., Selçuk Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD, KONYA
To investigate the effect of 5-Fluorouracil (5-FU) which is used for cancer chemotherapy on lipid peroxidation and antioxidant enzyme activities of rabbit erythrocyte. This study was performed on the New Zeland rabbits (albino type) with the weight of between 2300 and 2500 g. The rabbits were devided into four groups, and every group consisted 7 rabbits. Isotonic NaCl was applied to the Group I, 5-FU was applied intraperitonealy one a day for five days at 0900 with the following concentrations, 5 mg/kg, 10 mg/kg, 20 mg/kg, for Group II, Group III, and Group IV, respectively. In all groups, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and glucose 6-phosphate dehydrogenase (G6PD) activities and erythrocyte malondialdehyde (MDA) leves were studied. It was observed that while 5- FU doses were increasing, erythrocyte antioxidant enzyme activities were significantly decreased; however, erythrocyte MDA levels were significantly increased. It has been thought that oxidative stress occured by 5-FU depresses antioxidant defense system, but increases lipid peroxidation.Keywords: 5-Fluorouracil, Erythrocyte,
Antioxidant enzymes, Lipid peroxidationTurkiye Klinikleri J Med Sci 2000, 20:203-208
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