ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Value Of Deoxypyridinoline In The Diagnosis Of Osteoporosis
Hacer Savaş*, Ece Aydoğ**, Şebnem Kösebalaban***
* Uzm.Dr., SSK Etlik İhtisas Hastanesi Biyokimya Bölümü,
** Uzm.Dr., SSK Ankara Eğitim Hastanesi Fizik Tedavi Kliniği,
*** Doç.Dr., SSK Ankara Eğitim Hastanesi Biyokimya Bölümü, Şefi, ANKARA
Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration with a consequent increase in bone fragility and susceptibility to fracture. The noninvasive assessment of bone turnover has markedly improved in the past few years with the development of sensitive and spesific markers of bone formation and bone resorption. Several studies in recent years have shown that the pyridinium crosslinks of collagen (especially deoxypyridinoline) provide good urinary markers of collagen degradation, primarily reflecting bone resorption.
A total of 68 urine samples from patients and healthy volunteers were analysed by automated chemiluminesence immunassay system in SSK Ankara Hospital. They were classified according to their bone densitometric values; Postmenopausal osteoporotic group 1 (n=22); postmenopausal normal group 2 (n=26); premenopausal normal group 3 (n=20). Twenty patients who have high urinary Dpd were treated with alendronate for 4 months.
We found that the urinary Dpd/Cre values in postmenopausal osteoporotic group were higher than postmenopausal and premenopausal group had (p<0.05). We could not observe any significant relationship between bone densitometry and Dpd/Cre values in postmenopausal osteoporotic group (p>0.1). Serum Ca+2 and ALP values in postmenopausal group were higher than postmenopausal and premenopausal normal groups had. There was no significant relationship in Pi levels of blood and urine (p>0.05). We observed a prominent decrease in Dpd/Cre values of the patients treated with alendronate for 4 months compared to the values before treatment and after treatment (p<0.05).
In conclusion, this study showed that deoxypyridinoline which is a degradation product of collagen in the urine is a good marker in the diagnosis and follow up of osteoporosis.Keywords: Osteoporosis, DeoxypyridinolineTurkiye Klinikleri J Med Sci 2000, 20:264-271
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