ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Acute Effect Of Hemodialysis On Serum Concentrations Of Lipid Profile And Lipoprotein (a) Levels In End Stage Renal Failure Patients
Ayşegül Örs Zümrütdal*, H. Veli Atalay*, Başol Canbakan*,
Turan Turhan**, Süreyya AdanalI*
* Uz.Dr., Ankara Numune Hastanesi, 3.Dahiliye (Nefroloji) Kliniği,
** Uz.Dr., Ankara Numune Hastanesi, Biyokimya Bölümü, ANKARA
This study was performed to determine the predialysis values of serum lipid profile and Lp(a) levels in the end stage renal failure (ESRF) patients who would be dialysed for the first time- independent of hemodialysis effect- and to evaluate the acute effects of hemodialysis on lipid profile and Lp (a) levels after the first hemodialysis procedure.
Seventy ESRF and 70 healthy control cases were choosen. The predialysis values of patients were compared with control group and postdialysis values (which were taken 5 minutes later) were compared with predialysis values.
Comparing the predialysis values of the patients with controls the triglyceride, apolipoprotein B, VLDL and Lp(a) were found significantly higher in the patient group than the control group (p<0.001, <0.05, <0.001, <0.001 respectively). When postdialysis parameters were compared with predialysis parameters, there was a significant increase in LDL, apolipoprotein B, apolipoprotein A and Lp (a) levels in ESRF patients (p<0.001,<0.01,<0.001,<0.001 respectively).
Lp(a) level in ESRF patients was higher than the control group, independent of the hemodialysis effect, this should be related with dislipidemia of ESRF patients. Although the etiology of this acute harmful effect of hemodialysis on lipid profile and Lp (a) level is still unknown, this negative effect may increase in the long term by initation of chronic hemodialysis programme.Keywords: Lipoprotein (a), Hemodialysis,
Chronic renal failure, Acute changesTurkiye Klinikleri J Med Sci 2000, 20:286-290
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