ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Comparing Two Different Radiotherapy Schedules In Palliative Treatment Of Brain Metastasis
Mehmet KOÇ*, Dursun Dede*
*Yrd.Doç.Dr., Atatürk Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi AD, ERZURUM
Purpose: To investigate effect of the two different radiotherapy (RT) schedules on palliation and survival on the patients with brain metastasis.
Material and Methods: Forty patients whose brain metastasis had been diagnosed were randomised and treated with 300cGy/10 fractions or 200/20fractions. Primary tumor were; 55% lung, 15% Breast, 5% Choriocarcinoma, 5% Thyroid, 2.5%Malignant melanoma, 2.5% Larynx, 2.5% Nasopharynx and 12.5% Unknown prymary. Patients evaluated for possible associations wity survival such as Karnofsky Performance Status (KPS), Eastern Cooperative Oncology Group (ECOG) and Neurologic Functional Classification /NFC).
Results: Median survival were 4.3 months in first group (300cGy/10fr), 5.8 months in second group (200cGy/20fr). There were no significant differeces between two groups according to improving of symptoms, local control of disease, NFC, ECOG and overall survival. The disease free interval and KPS were significantly different in second group from first group (p=0.039, p=0.014). In univariete analysis, KPS³70, ECOG£1 and NFC=1 were found to be favourable prognostic factors (p=0.044, p=0.035) and (p=0.034). There were no significantly side effects in the patients during RT and post radiotherapy periods.
Conclusion: In treatment of brain metastasis, conventional fractions of RT may be useful to increase quality of life and survival.Keywords: Brain metastasis, prognostic factors,
radiotherapy, palliationTurkiye Klinikleri J Med Sci 2000, 20:279-285
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