ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effect Of Carnitine On Intensive Exercise Induced Decreasedglycogen, Accumulated Lactic Acid And Morphological Changesin Skeletal Muscle
Ömer COŞKUN*, Şükrü ÖTER**, Ahmet KORKMAZ**,
Şaban SEZEN*, Emin ÖZTAŞ***, Mehmet CINCIK***
* Uz.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD,
** Uz.Dr., GATA Fizyoloji AD,
*** Yrd.Doç.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD, ANKARA
80 adult male Sprague-Dawley rats were used to investigate the changes in skeletal muscle induced by intensive muscular exercise and the effects of carnitine. The rats were divided into 4 equal groups as control, carnitine, exercise and carnitine+exercise.
Carnitine was administered intraperitoneally, at a dose of 300 mg/kg/day dissolved in 3 cc saline, for 10 days. The same amount of saline was injected to the exercise and control groups. Swimming exercise was performed for 30 minutes after injections. Statistical comparisons were made by using post-ANOVA test.
Serum free carnitine, muscle carnitine and glycogen levels decreased significantly in exercise group. In the other groups these parameters found to remain in physiological levels.
Skeletal muscle preparations were examined morphologically by light microscope. Samples dyed by Haematoxylen-Eosin showed that muscle morphology in exercise group altered more than carnitine+exercise group. Also, muscle glycogen content was seen more in exercise group than carnitine+ exercise group, by Best Carmine dye.
In conclusion, it is possible to say that carnitine is a substance used during exercise and carnitine administration before intensive muscular exercise may prevent the decrease of muscle carnitine and glycogen contents.Keywords: L-Carnitine, Skeletal muscle, ExerciseTurkiye Klinikleri J Med Sci 2000, 20:325-333
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