ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Tumor Markers And Alcohol Consumption
Fatih GÜLTEKİN*, Namık DELİBAŞ**, Mehmet GÜRBİLEK***, Mehmet AKDOĞAN*,
Hüsamettin VATANSEV****, Mahmut ALAN****
* Yrd.Doç.Dr., Dept. of Biochemistry, Süleyman Demirel University, School of Medicine,
** Doç.Dr., Dept. of Biochemistry, Süleyman Demirel University, School of Medicine, Isparta
*** Doç.Dr., Dept. of Biochemistry, Selçuk University, School of Medicine,
**** Dr., Dept. of Biochemistry, Selçuk University, School of Medicine, Konya, TURKEY
Purpose: To find out whether tumor markers were useful to determine if there were some organs affected by alcohol.
Instution: Selçuk University, Faculty of Medicine, Dept. of Biochemistry, Konya, Turkey.
Materials and Methods: Serum concentrations of the tumor markers were examined in 33 alcohol consumers aged between 20-48 (mean 35.3±6.3) and 36 non-consumer aged between 18-55 (mean 37.8±10.3). Serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), prostate specific antigen (PSA), and carbohydrate antigen 19-9 (CA 19-9) levels were determined by using a solid-phase, two-site chemiluminescent enzyme immunometric assay. Routine methods were used for the measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) activities.
Results: Significant elevation in AFP (p<0.05), CEA (p<0.05), AST (p<0.01), GGT (p<0.001) was found in alcohol drinkers as compared to non-drinkers. AFP and CEA were found to have been correlated positively with age and alcohol consumption years (p<0.05, for all). There was also a significant correlation between serum GGT activity and the amount of alcohol consumed (p<0.01).
Conclusion: The increase of AFP, CEA levels, and AST, GGT activities in alcohol drinkers may reflect alcohol-induced liver affection.Keywords: Alpha-fetoproteins, Carcinoembryonic Antigen, Prostate-Specific Antigen, CA-19-9 AntigenTurkiye Klinikleri J Med Sci 2001, 21:49-53
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