ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Malformations In Chick Embryo Caused By Probable Embryotoxic Factors In The Sera Of Neonates With Meningomyelocele And Their Mothers
Ali Altan GÜNAYDIN*, Şaban SEZEN**, Ömer COŞKUN**, Mehmet CINCIK***,
Emin ÖZTAŞ***, Selçuk DUMAN****
* Dr., GATA Tıbbi Histoloji ve Embriyoloji AD,
** Uzm.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD,
*** Yrd.Doç.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD, ANKARA
**** Prof.Dr., Selçuk Üniversitesi Tıp Fakültesi Tıbbi Histoloji ve Embriyoloji AD, KONYA
The etiology of meningomyelocele is not clear. In our study, we investigated embryotoxic factor in order to contribute to the etiology. Serum; from six newborns aged 1-3 days; with meningomyelocele and from their mothers were collected under aseptic conditions. 20 µ1 of serum samples were injected to fertilized, 0. hour white eggs. Totally 114 experimental and 111 control eggs were used.
It was observed that in the experimental group, eggs showed a higher rate of embryo death and anomaly percentage. The observed anomalies were neural tube defect, gastrointestinal anomalies, chest and musculoskeletal defects and anophtalmus. In the experimental group also a slow development rate was observed. It is suggested that the possible cause of these anomalies may be a possible factor in the serum of meningomyelocele neonates or embryotoxic factor or factors transported from the mothers via placenta.Keywords: Meningomyelocele, Serum,
Embryotoxic factorTurkiye Klinikleri J Med Sci 2001, 21:25-30
|
|
|
|
|
