ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Intensive Muscular Exercise And Epinephrineon Serum Carnitine And Tissue Glycogen Levels
Ömer COŞKUN*, Şükrü ÖTER**, Ahmet KORKMAZ**, Emin ÖZTAŞ***, Şaban SEZEN*
* Uz.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD,** Uz.Dr., GATA GATA Fizyoloji AD,*** Yrd.Doç.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD,**** Uz.Dr., GATA Tıbbi Histoloji ve Embriyoloji AD, ANKARA
In this study, it was aimed to determine the additive effects of epinephrine on intensive muscular exercise and its relation with serum carnitine and muscle glycogen contents. Forty adult Sprague-Dawley rats were divided into 4 equal groups; control, exercise, epinephrine and epinephrine+exercise. 0.02 mg/kg/day epinephrine was administered intraperitoneally in 3 cc saline for 10 days. 3 cc saline was injected also to control and exercise groups. Swimming exercise was performed for 30 minutes after injections.
On the 10th day the animals were sacrificed by decapitation. Blood samples were taken for serum free carnitine and plasma lactate measurement. Then their musculus soleus were extracted for tissue glycogen and morphologic determination.
The definitely increase of serum lactate level in exercise and epinephrine+exercise groups showed the intensity of the swimming exercise applied. In exercise group, serum carnitine and muscle glycogen level decreased significantly, compared with controls. These results indicate that carnitine and glycogen consumption increased with exercise. In epinephrine exercise group, carnitine and glycogen levels decreased significantly, when compared with all other groups. In addition, the skeletal muscle morphology impaired more in epinephrine+exercise group than only exercise group. Nearby this findings, the only epinephrine group didn't show any statistically significant alteration.
As result, it is possible to say that epinephrine have an additive effect on exercise caused muscular structure impairment and decrease of carnitine and glycogen levels.Keywords: Epinephrine, L-carnitine, Muscle, SkeletalTurkiye Klinikleri J Med Sci 2001, 21:17-24
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