ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
The Effects Of Endosulfan On Activity Andkinetic Properties Of Lactic Dehydrogenase Enzyme: A Biochemical And Histopathological Study¶
Ergül Belge KURUTAŞ*, Figen DORAN**
* Dept. of Biochemistry, Medical School of Çukurova University,
** Dept. of Pathology, Medical School of Çukurova University, Adana, TURKEY
Endosulfan insecticide is a polychlorinated compound that is common used in agriculture fields. In recent years in Turkey, especially in Çukurova Region, it has been suggested that there would be a relation between the increased incidence of breast cancer and widely use of endosulfan. For this purpose, effect of endosulfan on activity and kinetic properties of lactic dehydrogenase enzyme in erythrocyte, liver, and breast tissues of mature Mus musculus were investigated. Sixty mature (30 control, 30 experimental) M. musculus, weighing between 23 and 40 g, were obtained from the Medical Experimental Surgery Research Center of Çukurova University. The effects of oral administration of endosulfan (0.24 mg per 100 g body weight) daily for 90 days (short term) and for 180 days (long term) were investigated. As a result, no effect on body and breast weights whereas an increase on liver weight and hepato/somatic index were observed in both short and long terms. Activity of lactic dehydrogenase enzyme in erythrocyte, liver and breast tissues showed significant increase. Although the kinetic properties of lactic dehydrogenase enzyme of erythrocyte and liver tissues were effected by endosulfan; breast tissue kinetic properties showed no significant changes.Keywords: Endosulfan, Mice, Lactic dehydrogenase,Turkiye Klinikleri J Med Sci 2001, 21:11-16
|
|
|
|
|
