ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Acute Effect Of Different Cellulosic Membraneson Proinflammatory Cytokines In Hemodialysis Patients
Mahmut Yavuz*, Alpaslan Ersoy**, Barbaros Oral***, Mustafa Güllülü*,
İsmail Aslanhan**, Kamil Dİlek*, Mustafa Yurtkuran*
Purpose: The proinflamatory cytokines such as interleukin-1b (IL-1b), interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) can contribute to the appearance of some complications in haemodialysis patients. It has been reported that cytokine production after dialysis treatment increase with bioincompatible membranes but is unaffected with the biocompatible membranes. In this study we aim to investigate whether the effects of different cellulosic membranes on proinflamatory cytokine production in one dialysis session play a role in the biocompatibility.
Materials and Methods: Fourty-seven haemodialysis patients who were being followed up in Uludağ University Medical Faculty Hemodialysis Unit were included into this study and they were divided into three groups regarding age, sex and dialysis hours. 15 patients in group-I had 4 hours of haemodialysis with triacetate, 16 patients in group-II with hemophan and 16 patients in group-III with cuprammonium membrane. IL-1b, TNFa, IL-6, C3c and C4 levels were measured before and after the dialysis in one session. Statistical analysis was performed with nonparametric tests.
Result: After the dialysis, the changes in IL-1b levels of CTA group (from 0.10 ± 0.3 to 1.83 ± 1.4), IL-1b and TNF-a levels of H group (from 0.04 ± 0.1 to 0.64 ± 0.9 and from 11.2 ± 6.6 to 27.4 ± 12.3, respectively), and IL-6 and TNF-a levels in CU group (from 2.4 ± 4.5 to 1.39 ± 3.0 and from 18.1 ± 13.2 to 40.3 ± 25, respectively) were significant when compared with the values before dialysis. There was no significant difference between predialysis cytokine levels among groups.
When the percentage changes in postdialysis cytokin levels in all three groups were compared with each other, while IL-6 levels of CU group were significantly decreasing according to those of CTA and H groups, IL-1b levels of CTA significantly increased. No difference was observed between the percentage changes in TNF-a levels. CTA and CU increased C3c and C4 levels and H only increased C4 levels. In addition, there was no difference between the percentage changes in C3c and C4 levels of all three group.
Conclusion: We came to the conclusion that the effects of different cellulosic membranes on cytokine production were different during hemodialysis session and therefore, there could also be difference between the biocompatibilities of these membranes.Keywords: Hemodialysis, Cellulosic membranes,Turkiye Klinikleri J Med Sci 2001, 21:192-196
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