ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Investigation Of Effects Of Vitamin E And N-acetylcysteine On Trachea And Lung Tissues Of Mice Exposed To Sulfur Dioxide And Cold Under Light Microscopy
Zühal Ergönül*, Dicle Balkancı**, Ayşen Erdem***, Nur Çakar****, Pergin Atilla*****
* Uzm.Dr., Hacettepe Üniversitesi Tıp Fakültesi Fizyoloji AD,
** Doç.Dr., Hacettepe Üniversitesi Tıp Fakültesi Fizyoloji AD,
*** Yrd.Doç.Dr., Hacettepe Üniversitesi Tıp Fakültesi Fizyoloji AD,
**** Prof.Dr., Hacettepe Üniversitesi Tıp Fakültesi Histoloji AD,
***** Uzm.Dr., Hacettepe Üniversitesi Tıp Fakültesi Histoloji AD, ANKARA
Purpose: Sulfur dioxide (SO2) pollution is one of the most frequent types of air pollution. Since SO2 concentration rises during the winter months, exposure to this toxic agent occurs in cold weather. In this study, the effect of the co-existence of both factors on the trachea and lung tissues and the protective effects of vitamin E and N-Acetylcysteine were investigated.
Materials and Methods: A study model was constructed in which low temperature and SO2 coexist. An apparatus was prepared to allow SO2 inhalation and it was placed in a cold room. The mice were grouped and exposed to 10 ppm SO2 or 0-4 ºC cold or both for a spesific period. Vitamin E and N-Acetylcysteine were administered to some of the groups and physiologic saline to the other groups. At the end of this procedure the trachea and lung tissues were extracted and histological investigations were carried out.
Results: In microscopic studies of the trachea, damaged apical membranes and desquamation of epithelium and loss of cilia were detected while the lung tissue was found to be normal. Effects of SO2 became more intense in cold. Vitamin E and N-Acetylcysteine were found to have various protective effects against SO2 and cold.
Conclusion: Protective effects of vitamin E against sulfur dioxide were not significant at room temperature. However in cold weather, in some areas it provides protection from cilial exfoliation caused by sulfur dioxide. N-Acetylcysteine has a stronger protective effect than vitamin E against epithelial exfoliation but cannot protect the cilia. All these data may help to demostrate that these substances may be used together as protective agents in Winter.Keywords: Sulfur dioxide (SO2), cold, Vitamin E,
N-AcetylcysteineTurkiye Klinikleri J Med Sci 2001, 21:186-191
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