ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Value Of Skeletal Alkaline Phosphatase Isoenzyme In Thediagnosis Of Bone Metastases And Comparison With Bone Scintigraphy
Hülya Ortapamuk*, Ali Arslan**, Seniha Naldöken*, Ayşegül Doğrar***,
Hulki Genç**, Mustafa Esen**
* Uz.Dr., Ankara Numune Hastanesi Nükleer Tıp Bölümü
** Uz.Dr., Ankara Numune Hastanesi Dahiliye Kliniği
*** Uz.Dr., Ankara Numune Hastanesi Biyokimya Bölümü, ANKARA
Purpose: Bone scintigraphy plays a major role in the diagnosis of bone metastases. The clinical utility of new biochemical markers of bone metabolism has recently been investigated in various bone diseases. This study evaluated the role of skeletal alkaline phosphatase that is one of the bone metabolism markers in comparison with bone scan in the diagnosis of bone metastases in cancer patients.
Material-Methods: Forty patients with newly diagnosed cancer were included in the study. Bone scanning and serum value of total alkaline phosphatase and skeletal alkaline phosphatase were obtained in all patients.
Results: In all patients who had bone metastases proven by scintigraphy had also significantly elevated total alkaline phosphatase and bone alkaline phosphatase values. We showed that skeletal alkaline phosphatase could become a useful marker in the evaluation of patients with newly diagnosed cancers as it seems to provide additional information about the skeletal status of these patients.
Conclusion: We thought that, when skeletal metastases are of concern in cancer patients, both bone scintigraphy and measurement of bone alkaline phosphatase seems to be advantagous for recognizing metastatic bone disease earlier. But, according to our findings, we believe that serum levels of the investigated markers cannot replace bone scintigraphy
in cancer patients for the early detection of bone metastases.Keywords: Skeletal alkaline phosphatase, Bone scintigraphy,
Bone metastasesTurkiye Klinikleri J Med Sci 2001, 21:180-185
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