ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Prenatal Diclofenac Sodium Exposure On Thearticular Cartilage Of The Rat In The Postnatal Period
Ersan ODACI*, Adnan KORKMAZ**, Bülent AYAS***, M. Çetin RAĞBETLİ****, Nusret ÇİFTÇİ*****
* Yrd.Doç.Dr. Ondokuz Mayıs Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD,
** Doç.Dr., Ondokuz Mayıs Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD,
*** Araş.Gör., Ondokuz Mayıs Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD,SAMSUN
**** Yrd.Doç.Dr., Yüzüncü Yıl Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD, VAN
***** Prof.Dr., Ondokuz Mayıs Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD, SAMSUN
It has been shown that nonsteroidal anti-inflammatory drugs (NSAIDS) affect the cartilaginous tissue structure by inhibiting the synthesis of proteoglycans. Rheumatic diseases during pregnancy raise the issue of using antirheumatic drug. However, there is a paucity of any published material that demonstrates how the fetal cartilage is affected by the NSAIDS. In this study, diclofenac sodium was given to pregnant rats for fifteen days. Controls received physicological saline (1ml) in the same period. On the postnatal twentieth week, the articulation cartilages of the pubs were processed for routine paraffin histology and stained with alcian blue, a specific dye for proteoglycans. The staining density of the matrix was evaluated in a blind fashion by four investigatigators. Grading of the staining density of the matrix was made according to the criteria of Haigh M. and Scott JE (1986). Two grades were used light (-) and dark (+). The staining density in the controls was significantly darker (+) than in the diclofenac treated group. This result suggests that use of diclofenac sodium during gestation affects the development of fetal cartilages by inhibiting the synthesis of proteoglycans and that this situation is also visible later in life.Keywords: Articular Cartilage, Rat, Diclofenac sodiumTurkiye Klinikleri J Med Sci 2001, 21:278-281
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