ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Metalloproteinases, Their Inhibitors Andrelated Physiological And Pathological Conditions
Saliha APAKKAN AKSUN*, Dilek ÖZMEN**, Oya BAYINDIR***
* Uz.Öğ., Ege Üniversitesi Tıp Fakültesi Biyokimya AD,** Doç.Dr., Ege Üniversitesi Tıp Fakültesi Klinik Biyokimya BD,*** Prof.Dr., Ege Üniversitesi Tıp Fakültesi Klinik Biyokimya BD, İZMİR
Matrix metalloproteinases (MMPs) are a homologuous family of enzymes containing a zinc ion at the active site and are capable of degrading extracellular matrix and basal membrane components.
These enzymes play an essential role in physiological states such as tissue remodeling, morphogenesis and wound healing and also in pathological processes such as tumor cell invasion and metastasis.
With the addition of several new MMPs to 7 previously identified enzymes from this family, today more than 18 enzymes are reported.
There are some factors that inhibit MMPs. Among these, specific tissue inhibitor of metalloproteinases (TIMPs) have an essential role in the regulation of the activity of these enzymes in vivo.
The ratio of MMPs to TIMPs changes in many physiological and pathological processes, consequently the balance between these substances seems to play an important role in the pathogenesis of various disorders. During the process of wound healing in hepatic tissues, increase in TIMP:MMP ratio may promote fibrosis by protecting deposited ECM from degradation by MMPs.
Many processes regarding reproduction including ovulation, implantation, gestation, lactation and involution, require TIMP and / or MMP activities.
Degradation of the extracellular matrix and basement membranes plays a crucial role in cancer invasion as well as in non neoplastic tissue remodelling processes.
MMPs play a prominent role in the invasion of malignant tumors of the central nervous system, head and neck, stomach, pancreas, colon, kidney, skin and prostate.
Angiotensin II and aldosterone have been shown to stimulate collagen synthesis while angiotensin II additionaly inhibits MMP I activity, which is the key enzyme for interstitial collagen degradation in the myocardium. These findings may serve as rationale for a therapy with angiotensin converting enzyme inhibition in congestive heart failure and dilated cardiomyopathy.
Both collagenous and elastic components display a degeneration consistent with the overexpression of proteolytic activity. İn particular, senescent dermal fibroblasts overexpress metalloproteinase activities that may explain the age related atrophy of ECM architecture.Keywords: Matrix metalloproteinases,
Tissue inhibitors of metalloproteinases,
Extracellular matrixTurkiye Klinikleri J Med Sci 2001, 21:332-342
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