ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Endosulfan On Hematologic Parameters In Mus Musculus
Ergül BELGE KURUTAŞ*, Figen DORAN**
* Dr., Çukurova Üniversitesi, Tıp Fakültesi Biyokimya AD,
** Dr., Çukurova Üniversitesi, Tıp Fakültesi Patoloji AD, ADANA
Purpose: To investigate the effect of endosulfan pesticide administration in different lengths of time on hematologic parameters in Mus musculus.
Material and Methods: Sixty mature Mus musculus (30 control, 30 experimental), weighing between 23 and 40 g, were obtained from the Medical Experimental Surgery Research Center of Çukurova University. The effect of oral administration of endosulfan (0.24 mg per 100 g body weight) daily for 90 and 180 days was investigated.
Results: There has been an observation that the leucocyte level increased in 90 days and levels of erythrocyte, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin decreased (p<0.05) but values of hematologic parameters in 180 days approached the control's.
Conclusion: While physiologic response of the hematologic parameters to endosulfan toxicity was developing in 90 days in the living, adaptation mechanism was completed in 180 days.Keywords: Endosulfan, Mature Mus musculus,
Hematologic ParametersTurkiye Klinikleri J Med Sci 2001, 21:359-362
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