ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Sialic Acid Concentrations In Patients With Non-insulindependent Diabetes Mellitus And Its Relation With Retinopathy
Ahmet ERDİL*, Ahmet TÜZÜN*, Arif YÖNEM**, M. Kemal ERBİL***
* Yrd.Doç.Dr., GATA Gastroenteroloji BD, ANKARA
** Yrd.Doç.Dr., GATA Haydarpaşa Eğitim Hastanesi Endokrinoloji BD, İSTANBUL
*** Prof.Dr., GATA Biyokimya BD, ANKARA
Background/aims: Diabetic retinopathy is an important complication of diabetes mellitus. It is supposed that the coexistent high blood glucose and sialic acid in diabetes mellitus play an important role. In this study, we investigated serum total sialic acid levels related to glysemic control, blood pressure, retinopathy and serum lipid levels in diabetic patients.
Methods: We selected 62 patients with type 2 diabetes mellitus as a research group of those 31 patients did not have any retinopathy, in the remaining 20 patients had background retinopathy, 11 patients had background retinopathy and maculopathy. As a control group we selected 31 normal (healthy) subjects at random and matched them for age and sex with patients.
Results: Serum total sialic acid levels in the patients were found significantly higher than normal subjects (p<0.001). Serum sialic acid levels were especially elevated in patients with diabetic retinopathy when compared to the group without retinopathy (p<0.01). In the patients with retinopathy, we found correlation between total serum sialic acid levels, erythrocyte sedimentation rate, systolic and diastolic blood pressures. In the patients without retinopathy, we found high correlation between total serum sialic acid levels, erythrocyte sedimentation rate, systolic blood pressures and fructozamine levels.
Conclusions: As a conclusion, gradually increasing sialic acid levels in diabetic patients by destroying the cell structure plays an important role in development of retinopathy. There is a relationship of sialic acid with high blood pressure that has an influence in retinopathy formation. It is possible to prevent excessive increasing of serum sialic acid levels by a good diabetic regulation and keeping blood pressure in normal ranges, thus development of this complication retinopathy can be decreased.Keywords: Sialic acid, Type 2 diabetes mellitus,
Diabetic retinopathyTurkiye Klinikleri J Med Sci 2001, 21:349-354
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