ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Glycoproteins And Biomedical Importance
Özlem YAVUZ*
* Yrd.Doç.Dr., Abant İzzet Baysal Üniversitesi Düzce Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD, DÜZCE
Glycoproteins contain covalently linked oligosaccharides that are small but structurally complex. There are two distinct types of sugar containing proteins that occur animal cells: glycoproteins and proteoglycans. Most of the proteins that are integral components of the plasma membrane and that function as receptors for hormones or other molecules in the circulation, or that mediate interactions between cells, are glycoproteins. In addition, many of the proteins of the endoplasmic reticulum and Golgi apparatus, and those that are secreted by cells, including serum and mucous proteins, are glycoproteins. Indeed, glycosylation is the major postsynthetic modification of proteins; it occurs either during the course of protein synthesis in the endoplasmic reticulum or once the protein has been synthesised and transported to the Golgi apparatus. The functions of carbohydrate chains of the resulting glycoproteins are diverse: they may stabilise the protein against denaturation, protect it from proteolytic degradation, enhance its solubility, or serve as recognition signals to facilitate cell-cell interactions.Keywords: Glycoproteins, Proteoglycans,
GlycosylationTurkiye Klinikleri J Med Sci 2001, 21:517-522
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