ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Copper, Zinc Levels And Superoxide Dismutase Activity In Cholelithiasis Cases
Ümmühani ÖZEL*, Ayşe BİLGİHAN**, Mete DOLAPÇI***, Mustafa SARYAL****,
Çınar YASTI****, Nuri Aydın KAMA*****
* Doktora Öğr., Gazi Üniversitesi Tıp Fakültesi Biyokimya AD,
** Doç.Dr., Gazi Üniversitesi Tıp Fakültesi Biyokimya AD,
*** Doç.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi 4. Genel Cerrahi Kliniği, Şef Yard.,
**** Op.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi 4. Genel Cerrahi Kliniği,
***** Doç.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi 4. Genel Cerrahi Kliniği, Şefi, ANKARA
It is known for long that reactive oxygen species may play an important role in the pathogenesis of many diseases. Early studies have shown that reactive oxygen species affect gallstone formation.
The aim of the present study was to investigate the serum superoxide dismutase (SOD) enzyme activities as a part of the antioxidant system and serum copper (Cu) and zinc (Zn) levels in patient with gallstones.
In these patients, decreased serum superoxide dismutase activities were observed compared to the healthy group (p<0.05). The control values were similar to the ones on the first postoperative day after cholecystectomy.
Serum Zn levels in cases of cholelithiasis were not statistically different from the healthy group (p>0.05). However, Zn levels did not also changed significantly on the first postoperative day (p>0.05).
In cases of cholelithiasis, serum Cu levels were decreased compared to the healthy group (p<0,05). The copper levels on the first postoperative day were similar to the ones in the healthy group.
Serum superoxide dismutase activities were restored to the normal values after surgical treatment. However, serum levels of copper and zinc which are the cofactors of superoxide dismutase have shown variations which are not revelant to superoxide dismutase activity.Keywords: Cholelithiasis, Superoxide dismutase,
Copper, ZincTurkiye Klinikleri J Med Sci 2001, 21:488-492
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