ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Role Of Transforming Growth Factor Beta 1 (tgf-b1) In Progress And Prognosis Of Bladder Cancer
Kenan Yenihayat*,Bülent Oktay**, H. Vuruşkan*, G. Filiz***, İsmet Yavaşçaoğlu****,
Ümit Şimşek**, Mustafa Özyurt**
* Uz.Dr.,Uludağ Üniversitesi Tıp Fakültesi Üroloji AD,
** Prof.Dr.,Uludağ Üniversitesi Tıp Fakültesi Üroloji AD,.
*** Yrd.Doç.Dr., Uludağ Üniversitesi Tıp Fakültesi Patoloji AD,
**** Doç.Dr.,Uludağ Üniversitesi Tıp Fakültesi Üroloji AD, BURSA
The goal of our study was to identify the patients at high risk of progression by assesing Transforming growth factor-beta1 (TGF-Beta 1) levels in the afflicted tissue and to offer cystectomy procedure at earlier stages.
We studied 30 patients who were diagnosed to have bladder cancer in our urology department between 1989-1999; 15 patients with no previous bladder cancer history were assigned as control group. Tissue sections prepared from paraffin embedded specimens were studied for their TGF-Beta1 content by immunohistochemical staining.
Compared to superficial tumors (Ta,T1),TGF-Beta1 levels were markedly reduced in invasive bladder tumors (p<0.001). High grade tumors (grade 3) had lower TGF-Beta1 levels than low grade tumors (grade 1 and 2)(p<0.01). Consistently,compared to normal epithelium, an increased TGF-Beta 1 level was noted in the afflicted tissue (p=0.05).
In light of these findings, a link between decreased TGF-Beta 1 levels and the progressive, aggressive and metastatic behaviour of the dissease can be established. Further studies should aim at quantifying the TGF-Beta 1 levels in the tissue and determining the value that allows the surgeon to select the optimal cyctectomy procedure at earlier stages.Keywords: Bladder cancer, TGF-Beta 1, Progression, Cyctectomy, GradeTurkiye Klinikleri J Med Sci 2001, 21:470-474
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